À PROPOS DE NOUS

Prévenir l'obésité grâce à des interventions personnalisées, adaptées à la biologie et aux comportements de chacun

BETTER4U est un projet d’une durée de quatre ans (2023-2027) financé par Horizon Europe, qui vise à développer des recherches approfondies et des interventions innovantes pour lutter et inverser l’augmentation général de l’obésité et du surpoids.

Qu'est-ce que l'obésité ?

L’obésité est l’accumulation d’un excès de graisse dans les tissus. Elle est considérée comme une maladie chronique non transmissible (MNT) à part entière. De plus, l’obésité augmente également le risque pour un individu atteint de développer d’autres MNT chroniques, telles que le diabète de type 2, les maladies cardiovasculaires et rénales, ainsi que certains types de cancer.

La prévalence du surpoids et de l’obésité au sein de la population mondiale a augmenté, au cours des dernières décennies, faisant de l’obésité une épidémie silencieuse à l’origine de plus de 4 millions de décès chaque année — dont 1,2 million rien qu’en Europe, selon les chiffres de l’Organisation mondiale de la santé (OMS).

Comment lutter contre l’obésité à l’échelle mondiale ?

Pour comprendre le surpoids, il convient de prendre en compte tous les déterminants, en intégrant non seulement les facteurs bien établis tels qu’une trop faible activité physique, de mauvaises habitudes alimentaires et rythmes de sommeil —facteurs avérés de la prise de poids —, mais aussi en abordant des aspects souvent négligés comme l’environnement  sociale et économique. Dans le cadre du projet BETTER4U, il est prévu d’évaluer, dans une perspective multifactorielle, les conditions en cause de la prise de poids en population générale et au sein de groupes spécifiques.

Pour lutter contre cette épidémie, BETTER4U contribuera à l’élaboration d’interventions de perte de poids personnalisée et fondées sur des données probantes. Cette initiative vise à aider les utilisateurs à mener une vie plus saine et à bénéficier d’une espérance de vie plus longue.

Objectifs

Lutter contre l’obésité : une approche personnalisée et fondée sur des données scientifiques

Les principaux objectifs de BETTER4U sont les suivants :

1

Mener des analyses approfondies des paramètres potentiellement liés au développement de l’obésité qui ont été historiquement négligés, tels que la génétique, le microbiome, les facteurs socio-économiques, la géographie, la culture et le mode de vie, afin d’expliquer les complexités de la prise de poids tout au long de la vie.

2

Élaborer une méthodologie d’intervention préventive contre la prise de poids, s’appuyant sur une technologie d’intelligence artificielle (IA) dont les connaissances proviennent d’une étude pilote menée dans 7 pays d’Europe. L’efficacité de la méthodologie BETTER4U sera évaluée dans le cadre d’un essai clinique intégrant un suivi en temps réel assisté par la technologie.

3

Identifier les obstacles à la mise en œuvre, les facteurs facilitateurs et les résultats susceptibles de déboucher sur l’élaboration et la diffusion de recommandations en matière de prévention de l’obésité, selon une approche de soins centrée sur la personne.

partenaires

Les experts à l’origine du projet

Le consortium du projet regroupe 28 organisations partenaires représentant différentes perspectives : des professionnels de santé des secteurs public et privé, des universités de renom, des instituts de recherche et des entités sociales telles que des ONG ou collectivités territoriales, qui œuvrent pour lutter contre l’augmentation de la prévalence du surpoids et de l’obésité dans nos sociétés.

Harokopio University of Athens, Greece, excels in health-related research, holding a national leading position and global rankings. The Department of Nutrition and Dietetics is a leader in applied science in its field, focusing on improving health through research, teaching, and international collaborations. HUA’s Department of Informatics and Telematics advances Computer Science, mainly in web applications, big data and machine learning.

To learn more, visit the website for HUA’s Department of Nutrition and Dietetics at https://www.ddns.hua.gr/en/home/ .

CEIDSS is a non-profit Research Organization working in health promotion focused on the social determinants of health.  Its mission is to produce innovative intervention research to improve the health status of the population, with an emphasis education on health determinants and risk factors linked with non-communicable diseases. 
CEIDSS works in association with local and national authorities. While participating in European projects, CEIDSS has a strong experience in developing national and international comprehensive programs on tackling malnutrition, aligned with health strategies and priorities.

Claude Bernard University Lyon 1 and Hospices Civils de Lyon are the directing institutions of the Rhône-Alpes Human Nutrition Research Center (CRNH-RA), a research infrastructure open to the scientific community to facilitate and conduct research programs aimed at improving nutrition for health and well-being. Collaborating with experts and industries, notably the Lyfe Institute Research Centre for projects like Better4U, we strive for tasty, healthy, sustainable meals, transmitting original scientific knowledge.

For the Better4U project, UCBL are mainly involved in the definition, implementation, and execution of a pilot study and the clinical study as an investigative center. Hospices Civils de Lyon are responsible for the delegated sponsorship of the clinical trials.

COPSAC is a clinical research unit for pediatric asthma research aiming to develop evidence-based prevention strategies. COPSAC comprises a multidisciplinary medical specialties cluster and participates in national and international research collaborations. 
Amongst its research lines, the study of Endo phenotyping, gene scanning, is based on daily diary cards and comprehensive longitudinal objective assessments exploring systems biology and gene-environment interactions in the origin of atopic diseases. 

EUFIC, the European Food Information Council, is a non-profit organisation that offers accessible, appealing and actionable science-based information on food and health – to inspire and empower both the general public and health professionals.

EUFIC has extensive expertise in translating and tailoring scientific results into digestible materials. Versatile audio-visual materials are produced to satisfy the needs of different audiences, from simple infographics explaining basic food and health concepts, to thorough reviews of scientific literature.

EUFIC’s communication tools and networks ensure broad and effective dissemination.

The International Hellenic University (IHU) is based in Thessaloniki, Greece, and it recently merged with 3 major technological academic institutions in Greece. The Dpt. of Nutritional Sciences & Dietetics of IHU (NUTR.IHU) was the first tertiary education department of its kind in Greece and has many years of experience in educational and research activities in the areas of Human Nutrition, Dietetics, Adult and Childhood Obesity, and Nutrition Informatics, with multiple active research laboratories.

Karolinska Institutet (KI) was established in 1810 and is globally recognized as a frontrunner of medical universities and the leading medical university in Sweden. KI is dedicated to biomedical sciences, annually giving the Nobel Prize in Medicine. KI hosts around 600 research groups spanning all medical domains. Among them, the IMPACT research group focuses on preventing childhood and pregnancy-related overweight and obesity. Additionally, the IMPACT group offers programs in Nutrition in affiliation with the Centre for Nutrition at KI. 

The Department of Epidemiology has a tradition of excellent teaching and innovative, interest-driven research in the epidemiology of cancer, cardiovascular disease, and other chronic diseases, as well as in epidemiologic methodology. To improve the public’s health the Department is training epidemiologists advancing knowledge concerning the causes and prevention of disease and the promotion of health.

The University of Cyprus (UCY) leads in research, hosting a Center of Excellence in Biobanking since 2011. Upgraded through EU funding in 2019, it oversees biobank.cy, a clinical site for BETTER4U trials. UCY excels with €30.9 million in 2022 research funding, participating in 370 projects, ranking 1st in Cyprus under Horizon Europe and 137th in Horizon 2020. UCY’s achievements include 3 Teaming in Excellence projects, 28 MSCA projects, and 69 Erasmus+ projects, positioning it as a prominent contributor to European research and education.

The University of Helsinki is in Helsinki, Finland. It is the oldest and largest institution of academic education in the country. The university is an international scientific community of 40,000 students and researchers. In international university rankings, the University of Helsinki typically ranks among the top 100. Through the power of science, the University has contributed to society, education and welfare since 1640.

FIMM – Institute for Molecular Medicine Finland is a translational research institute focusing on human genomics and precision medicine as part of the Helsinki Institute of Life Science HiLIFE at the University of Helsinki.

The University of Navarra is a Spanish non-profit Christian-inspired university. It is among the best Spanish universities according to several rankings. 

Its values are summarized by the words learning, living and serving. Since its origins it has always been committed to research, both in scientific and humanistic areas with the pursuit of being committed to the truth wherever it is and wherever it comes from.

Ghent University is an open, pluralistic, and socially engaged university. It is more than 200 years old, offers more than 200 programs (including 64 English-taught master’s programs) and conducts in-depth research within a wide range of scientific domains. 

Our credo is Dare to Think: we are a haven for courageous thinkers.

SWPS is a private university established in 1996, with a strong community of over 300 permanent faculty of researchers and experienced academics, who teach over 14,500 students enrolled in 35 undergraduate, graduate and doctoral programs, across five campuses located in major cities in Poland. Our broad education offer includes 16 programs taught entirely in English to over 1,100 international students from more than 80 countries.

See https://english.swps.pl/

The University of Tartu founded in 1632, is Estonia’s oldest and largest university. Serving as Estonia’s research and training hub, UTARTU excels in diverse fields, managing work-intensive projects and ranking among the top 1.2% globally. The Institute of Genomics, a merger of the Estonian Genome Centre and Estonian Biocentre, explores the impact of genetic, lifestyle, and environmental factors on health. Hosting the Estonian Biobank, it comprises 200,000 individuals with comprehensive health and genomic data, fostering groundbreaking research.

Helmholtz Munich is a research institution focusing on metabolic and environmental health, bioengineering, and computational health. 

At the Institute of Epidemiology our mission is to understand the protective and harmful effects of the environment, genes and lifestyle on human health and disease using population-based epidemiology approaches. Knowledge of these interactions leads to prevention and intervention approaches for cardiometabolic diseases and allergies.

Since its foundation, Vrije Universiteit Amsterdam has stood for scientific and value-driven education, research and knowledge transfer. We are free thinkers with expertise and A Broader Mind. And we work together to build a better world for people and the planet.

EASO is the leading voice of obesity science, medicine, and community in Europe, representing scientists, health care professionals, physicians, public health experts and patients. Established in 1986, EASO is a federation of professional membership associations from 36 European countries.

Established in 2017 at the University of Vienna’s Law School, the Department of Innovation and Digitalisation in Law specializes in addressing legal issues in the modern media and information society arising from rapid technological innovations. With a focus on information technology, intellectual property law, privacy/data protection, copyright, e-commerce, consumer protection law, Legal Tech, and innovations in the legal field, the department actively engages in multidisciplinary third-party funded projects, particularly in health care and law enforcement.

The Weizmann Institute is devoted to wide-ranging multidisciplinary exploration of the natural, exact, and life sciences. There are 2,500 scientists, students, and supporting staff at the institute. Weizmann is widely recognized as an international leader in systems and computational biology, due to several of its scientists in the field.

WINGS provides complete digital solutions to transform vertical business sectors such as; Environment, Utilities and Infrastructures, Production & Manufacturing, Service Sectors as well as Healths. While in this last one WINGS has developed STARLIT, a modular product suite for digital health and wellness based on Artificial Intelligence. STARLIT incorporates diverse devices, for the monitoring and collection of vital signs, as well as other measurements and features e.g. location, emergency calls, altitude, acceleration, activity, etc. WINGS will exploit its work in BETTER4U to enhance STARLIT with mechanisms for monitoring and biological and life-style determinants of weight gain.

The University of Cagliari was founded in 1620.

25.000 students, 6 faculties, 15 departments, 1 university hospital, and about 100 programmes

~1000 professors and ~1000 administrative personnel.

Department of Surgical Science – Metabolomics research group has more than years experience in the scientific study of chemical processes involving metabolites, 80 international collaborations and several EU funded projects sucessfully closed in the past years.

Bioclinica laboratories are a group of private medical laboratories (15 laboratories and 151 collection sites). The first laboratory was founded in 1992, in Timisoara. In over 30 years, BIOCLINICA consolidated its activity by establishing new laboratories. We have direct representation in 32 countries throughout Romania. All Bioclinica group laboratories are accredited in accordance with SR EN ISO 15189.

The Aristotle University of Thessaloniki (AUTH) is the Greek largest university, founded in 1925 and comprising of 12 faculties and 42 schools. The university has an enrollment of 81,500 students, covering multidisciplinary scientific fields. The teaching and research staff numbers more than 2,700 people. The main university campus is close to the center of Thessaloniki and covers over 23 hectares. AUTH will be represented by the Multimedia Understanding Group with a long record of collaboration in EU projects.

Tampere University Hospital as part of the Wellbeing Services county Pirkanmaa provides expertise in nearly all medical specialties in Pirkanmaa area in Finland. The Clinical chemistry research group is directly connected to both Tampere University Hospital and Tampere University enabling the collection of high-quality cohorts and access to excellent research infrastructure – Clinical chemistry functions as a research unit in the interface of laboratory medicine and university research.

The University of Bern, at the heart of Switzerland, is a hub of global connections and local engagement. It forges partnerships across science, medicine, business, and politics, emphasizing ethical responsibility. Renowned for problem-oriented research, the university serves as a key regional educator and industry promoter. It is dedicated to equal opportunities, fostering work-life balance, ensuring safe environments, and actively increasing gender diversity across all faculty levels.

From humble beginnings in 1945, the Queensland Institute of Medical Research, now known as QIMR Berghofer, is one of Australia’s most successful medical research institutes, translating discoveries from bench to bedside for a better future of health.

Born in Bradford (BiB), a renowned research program focused on factors influencing family health and happiness. Operating in collaboration with local entities, BiB manages three birth cohorts (BiB Cohort, Born in Bradford’s Better Start, and BiB4All) in total the program collects data on over 12,400 families. Each division conducts longitudinal studies, administers surveys, and collects biological samples to explore health trends. Applying its findings to science-based guidelines. Additionally, Connected Bradford compiles longitudinal data for 600,000 citizens, aiming to enhance healthcare pathways. 

Throughout our history, we’ve fostered social justice and improved lives through academic excellence. And we continue to live and breathe this spirit today, not because it’s simply ‘the right thing to do’ but for what it helps us achieve and the intellectual brilliance it delivers.

Our reformer heritage informs our conviction that great ideas can and should come from anywhere. It’s an approach that has brought results across the globe, from the communities of east London to the favelas of Rio de Janeiro.

We continue to embrace diversity of thought and opinion in everything we do, in the belief that when views collide, disciplines interact, and perspectives intersect, truly original thought takes form.

Extra information

Comité consultatif externe

The main objectives of BETTER4U are to:

Vagelis Papakonstantinou

Professor on Personal Data Protection Law at the Faculty of Law & Criminology of the Free University of Brussels (VUB, Vrije Universiteit Brussel), focusing also on Cybersecurity, Intellectual Property, and the broader topic of technology regulation. He is the director of VUB’s Cyber and Data Security Lab (CDSL), as well as, a core member of VUB’s Research Group on Law Science Technology & Society (LSTS) and the Brussels Privacy Hub.

José M. Ordovás

Ph.D., is Professor of Nutrition and a Senior Scientist at the USDA-Human Nutrition Research Center on Aging at Tufts University in Boston, Massachusetts where he also is the Director of the Nutrition and Genomics Laboratory. In addition, he is Professor of Genetics and Pharmacology at the School of Biomedical Sciences. In Spain, he is leader of the Nutritional Genomics and Epigenomics Group at IMDEA-Food, Madrid.

Frank Hu

MD, MPH, PhD, is the Fredrick J. Stare Professor of Nutrition and Epidemiology and Chair of the Department of Nutrition at the Harvard T.H. Chan School of Public Health. He is also Professor of Medicine at Harvard Medical School and Brigham and Women’s Hospital. His major research interests include epidemiology and prevention of cardiometabolic diseases through diet and lifestyle; gene-environment interactions and risk of obesity and type 2 diabetes; nutritional metabolomics in type 2 diabetes and cardiovascular disease; and nutrition transition, metabolic phenotypes, and cardiovascular disease in low and middle-income countries.

Dr. Fariba Ahmadizar

is an Assistant Professor in Molecular (Pharmaco) Epidemiology at UMC Utrecht and a visiting scientist at Harvard T.H. Chan School of Public Health. Her research focuses on molecular epidemiology, particularly in diabetes precision medicine, using omics approaches (genomics and metabolomics) to predict and understand complications of type 2 diabetes, including those affecting the brain, heart, liver, and kidneys.

Sophie Visvikis-Siest

PhD Director of Research in INSERM for 24 years and head of INSERM and University of Lorraine Research Units in Nancy: “Interactions Géne-Environnement en Physiopathologie Cardio-Vasculaire” (IGE-PCV) for 15 years. She has aPhD on Genetic Epidemiology of Cardiovascular Diseases at the University of Nancy and Her main Research interests are in the domain of public health, personalised medicine, prevention, genetic epidemiology, genomics and pharmacogenomics, cardio-vascular
diseases, VEGF-A and inflammation.