Researchers from the University of Helsinki, a partner of the BETTER4U project, have published a paper examining proteomic associations with both fluctuations and long-term changes in BMI over a 40-year follow-up period.

While some studies have explored associations between weight change and blood proteins, most have been intervention-based, offering limited insight into proteomic associations with long-term weight gain. In those studies, it remains unclear whether plasma proteins are related to BMI fluctuation over time.

This study investigates associations of long-term BMI changes and fluctuations with over 1000 plasma proteins involved in cardiometabolic and inflammation functions. The findings of this study underscore the substantial role of environmental factors in shaping proteome-BMI associations over adulthood.

Obeso, A., Drouard, G., Palviainen, T., Wang, X., Ollikainen, M., Silventoinen, K., & Kaprio, J. (2025). Proteomic associations with fluctuation and long‐term changes in BMI: A 40‐year follow‐up study. Diabetes, Obesity and Metabolism. doi: 10.1111/dom.16448. Epub ahead of print. PMID: 40344339